Journal of Veterinary Behavior: Clinical Applications and Research
Volume 4, Issue 3 , Pages 118-126 , May 2009

Use of memantine in treatment of canine compulsive disorders

  • Barbara M. Schneider, Dr. Med. Vet.

      Affiliations

    • Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts
  • ,
  • Nicholas H. Dodman, BVMS

      Affiliations

    • Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts
    • Corresponding Author InformationAddress for reprint requests and correspondence: Nicholas H. Dodman, BVMS, 200 Westborough Road, North Grafton, MA 01536; Phone: (508) 887-4665; Fax: (508) 839-8734
  • ,
  • Louise Maranda, DMZ MSc PhD

      Affiliations

    • Wildlife Medicine, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts

References 

  1. Arnold PD, Rosenberg DR, Mundo E, Tharmalingam S, Kennedy JL, Richter MA. Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology. 2004;174:530–538
  2. Arnold PD, Sicard T, Burroughs E, Richter MA, Kennedy JL. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch. Gen. Psychiatry. 2006;63:769–776
  3. Breitschwerdt EB, Breazile JW, Broadhurst JJ. Clinical and electroencephalographic findings associated with ten cases of suspected limbic epilepsy in the dog. J. Am. Anim. Hosp. Assoc. 1979;15:37–50
  4. Denenberg S, Landsberg GM, Horwitz D, Seksel K. Comparison of cases referred to behaviorists in three different countries. In:  Mills DS editors. Current issues and research in veterinary behavioral medicine: papers presented at the Fifth International Veterinary Behavior Meeting. West Lafayette, IN: Purdue University Press; 2007;In press
  5. Deutsch SI, Mastropaolo J, Riggs RL, Rosse RB. The antiseizure efficacies of MK-801, phencyclidine, ketamine, and memantine are altered selectively by stress. Pharmacol. Biochem. Behav. 1997;58:709–712
  6. Dickel DE, Veenstra-Vanderweele J, Cox NJ, Wu X, Fischer DJ, Van Etten-Lee M, et al. Association Testing of the Positional and Functional Candidate Gene SLC1A1/EAAC1 in Early-Onset Obsessive-compulsive Disorder. Arch. Gen. Psych. 2006;63:778–785
  7. Dodman NH, Bronson R, Gliatto J. Tail chasing in a Bull Terrier. J. Am. Vet. Med. Assoc. 1993;202:758–760
  8. Dodman NH, Knowles KE, Shuster L, Moon-Fanelli AA, Tidwell AS, Keen CL. Behavioral changes associated with suspected complex partial seizures in Bull Terriers. J. Am. Vet. Med. Assoc. 1996;208:688–691
  9. Dodman NH, Shuster L, Nesbitt G, Weissman A, Lo W-Y, Chang W-W, et al. The use of dextromethorphan to treat repetitive self-directed scratching, biting, or chewing in dogs with allergic dermatitis. J. Vet. Pharmacol. Therap. 2004;27:99–104
  10. European Medicine Agency Web Site, January 25, 2008. Scientific discussion. Available at: www.emea.europa.eu/humandocs/PDFs/EPAR/axura/094802en6.pdf.
  11. Goldberger E, Rapoport JL. Canine acral lick dermatitis: response to the antiobsessional drug clomipramine. J. Am. Anim. Hosp. Assoc. 1991;27:179–182
  12. Guy W. Early Clinical Drug Evaluation Unit (ECDEU) Assessment Manual for Psychopharmacology. 1976;76–338Revised. N.I.M.H. publication D.H.E.W. publ NO (Adm)
  13. Hewson CJ, Luescher UA, Ball RO. Measuring change in the behavioural severity of canine compulsive disorder: the construct validity of categories of change derived from two rating scales. Appl. Anim Behav. Sci. 1998;60:55–68
  14. Hewson CJ, Luescher UA, Parent JM, Conlon PD, Ball RO. Efficacy of clomipramine in the treatment of canine compulsive disorder. J. Am. Vet. Med. Assoc. 1998;213:1760–1766
  15. Karno M, Golding JM, Sorenson SB, Burnam MA. The epidemiology of obsessive-compulsive disorder in five U.S. communities. Arch. Gen. Psychiatr. 1988;45:1094–1099
  16. Kohl BK, Dannhardt G. The NMDA receptor complex: a promising target for novel antiepileptic strategies. Curr. Med. Chem. 2001;8:1275–1289
  17. Luescher UA, McKeown DB, Halip J. Stereotypic and obsessive-compulsive disorders in dogs and cats. Vet. Clin. N. Am. Sm. Anim. Pract. 1991;21:401–413
  18. Maurer BM, Dodman NH. Animal Behavior Case of the Month. J. Am. Vet. Med.Assoc. 2007;231:536–539
  19. McLean MJ, Gupta RC, Dettbarn WD, Wamil AW. Prophylactic and therapeutic efficacy of memantine against seizures produced by soman in the rat. Toxicol. Appl. Pharmacol. 1992;112:95–103
  20. McLean PD, Whittal ML, Thordarson DS, Taylor S, Sochting I, Koch WJ, et al. Cognitive versus behavior therapy in the group treatment of obsessive compulsive disorder. J. Consult. Clin. Psychol. 2001;69:205–214
  21. Moon-Fanelli AA, Dodman NH. Description and development of compulsive tail chasing in terriers and response to clomipramine treatment. J. Am. Vet. Med. Assoc. 1998;212:1252–1257
  22. Overall KL, Dunham AE. Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000. J. Am. Vet. Med. Assoc. 2002;221:1445–1452
  23. Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist—a review of preclinical data. Neuropharmacology. 1999;38:735–767
  24. Pasquini M, Biondi M. Memantine augmentation for refractory obsessive-compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2006;30:1173–1175
  25. Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. NeuroRx. 2006;3:69–81
  26. Poyurovsky M, Weizman R, Weizman A, Koran L. Memantine for treatment-resistant OCD. Am. J. Psychiatry. 2005;162:2191–2192
  27. Rapoport JL, Ryland DH, Kriete M. Drug treatment of canine acral lick: an animal model of obsessive-compulsive disorder. Arch. Gen. Psychiatry. 1992;49:517–521
  28. Rendon RA, Shuster L, Dodman NH. The effect of the NMDA receptor blocker, dextromethorphan, on cribbing in horses. Pharmacol. Biochem. Behav. 2001;68:49–51
  29. Seksel K, Lindeman MJ. Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study. Aust. Vet. J. 2001;79:252–256
  30. Stewart S, Fagerness JA, Platko J, Smoller JW, Scharf JM, Illmann C, et al. Association of the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder. Am. J. Med. Genetics. 2007;144B:1027–1033
  31. Torres AR, Prince MJ, Bebbington PE, Bhugra D, Brugha TS, Farrell M, et al. Obsessive-compulsive disorder: prevalence, comorbidity, impact and help-seeking in the British national psychiatric morbidity survey of 2000. Am. J. Psychiatry. 2006;163:1978–1985

PII: S1558-7878(08)00223-2

doi: 10.1016/j.jveb.2008.10.008

Journal of Veterinary Behavior: Clinical Applications and Research
Volume 4, Issue 3 , Pages 118-126 , May 2009