Journal of Veterinary Behavior: Clinical Applications and Research
Volume 2, Issue 2 , Pages 40-46, March 2007

Effect of alpha-casozepine (Zylkene) on anxiety in cats

  • Claude Beata, DVM

      Affiliations

    • CETACE Sarl, 353A, bd Grignan, 83000 Toulon, France
    • Corresponding Author InformationAddress for reprints and correspondence information: Claude Beata, DVM, CETACE Sarl, 353A, bd Grignan, 83000 Toulon, France.
    • ,
  • Edith Beaumont-Graff, DVM

      Affiliations

    • 145, route d’Avignon, 30000 Nîmes, France
    • ,
  • Victoria Coll, DVM

      Affiliations

    • Clinica Veterinaria Vetercans, 22 Avenida Ballester, Viladecans-Barcelona, Spain
    • ,
  • Jacques Cordel, DVM

      Affiliations

    • 4, avenue du Marĕchal de Lattre de Tassigny, 69500 Bron, France
    • ,
  • Muriel Marion, DVM

      Affiliations

    • Clinique Vĕtĕrinaire de Montolivet, 234, rue Charles Kaddouz, 13012 Marseille, France
    • ,
  • Nicolas Massal, DVM

      Affiliations

    • 389, bd de la Paix, 64000 Pau, France
    • ,
  • Nathalie Marlois, DVM

      Affiliations

    • Clinique Vĕtĕrinaire, 46, rue A. Bĕrard, 01500 Ambĕrieu en Bugey, France
    • ,
  • Jerome Tauzin, PhD

      Affiliations

    • Research and Development, Ingredia Inc., 51-53, avenue F. Lobbedez, BP 946, 62033 Arras Cedex, France

Abstract 

The putative effects of a tryptic bovine αs1-casein hydrolysate on anxious disorders in cats was investigated. This product is known as alpha-casozepine and patented under the name of Zylkene (Ingredia, Arras, France). Within veterinary practices, 34 cats were recruited by certified behaviorist surgeons. This 56-day trial against placebo showed the statistically positive effect of this product in the management of anxious disorders such as social phobias in cats. Global score, as well as different items (fear of strangers, contact with familiars, general fears, fear-related aggressions, autonomic disorders), were all significantly improved by the use of this natural decapeptide.

Keywords: anxiety, cat, alpha-casozepine, Zylkene, milk, stress

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PII: S1558-7878(07)00039-1

doi:10.1016/j.jveb.2007.02.002

Journal of Veterinary Behavior: Clinical Applications and Research
Volume 2, Issue 2 , Pages 40-46, March 2007

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