Effect of alpha-casozepine (Zylkene) on anxiety in cats

Abstract

The putative effects of a tryptic bovine αs1-casein hydrolysate on anxious disorders in cats was investigated. This product is known as alpha-casozepine and patented under the name of Zylkene (Ingredia, Arras, France). Within veterinary practices, 34 cats were recruited by certified behaviorist surgeons. This 56-day trial against placebo showed the statistically positive effect of this product in the management of anxious disorders such as social phobias in cats. Global score, as well as different items (fear of strangers, contact with familiars, general fears, fear-related aggressions, autonomic disorders), were all significantly improved by the use of this natural decapeptide.

Keywords: anxiety, cat, alpha-casozepine, Zylkene, milk, stress

a CETACE Sarl, 353A, bd Grignan, 83000 Toulon, France

b 145, route d’Avignon, 30000 Nîmes, France

c Clinica Veterinaria Vetercans, 22 Avenida Ballester, Viladecans-Barcelona, Spain

d 4, avenue du Marĕchal de Lattre de Tassigny, 69500 Bron, France

e Clinique Vĕtĕrinaire de Montolivet, 234, rue Charles Kaddouz, 13012 Marseille, France

f 389, bd de la Paix, 64000 Pau, France

g Clinique Vĕtĕrinaire, 46, rue A. Bĕrard, 01500 Ambĕrieu en Bugey, France

h Research and Development, Ingredia Inc., 51-53, avenue F. Lobbedez, BP 946, 62033 Arras Cedex, France

Address for reprints and correspondence information: Claude Beata, DVM, CETACE Sarl, 353A, bd Grignan, 83000 Toulon, France.

PII: S1558-7878(07)00039-1

doi:10.1016/j.jveb.2007.02.002

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